Clinical outcomes in newborns of pregnant women affected by respiratory infection due to COVID-19
DOI:
https://doi.org/10.26694/repis.v11i1.6613Keywords:
Infant, Newborn, COVID-19, Pregnant WomenAbstract
Objectives: To describe the clinical outcomes in newborns of pregnant women diagnosed with COVID-19. Methodology: This is an observational and retrospective field research, with a cross-sectional design, conducted in a public reference maternity hospital. The sample consisted of 191 medical records of women who had a diagnosis of COVID-19 at the time of delivery, from March 2020 to March 2021. Results: Most pregnant women were in their first and second pregnancies (29.32% and 31.94%, respectively), with the age group of 29 to 33 years representing 24.60%. A total of 25 pregnant women had previous abortions, while 16 underwent uterine surgery. Diabetes was observed in 25 pregnant women and hypertension in 34. There were 92 cases of Flu Syndrome identified and 14 hospitalizations due to pre-eclampsia. Regarding the Apgar evaluation, most newborns scored from 7 to 10 (86.39%), indicating good vitality. The term category included 64.40% of newborns, and 178 newborns were discharged. Implications: In light of the pandemic scenario and the uncertainties generated by COVID-19 infection during pregnancy, it is essential to maintain surveillance and systematic monitoring of maternal and neonatal conditions. Thus, the importance of continuous production of scientific evidence that supports clinical decisions and public policies aimed at maternal and child health should be reinforced, especially in situations of health emergencies, pandemic evolution, and the emergence of variants. It is essential to continue monitoring outcomes to support clinical practices and public health policies, ensuring safe pregnancies and births in the face of this challenging global situation
References
Brasil. Painel de casos de doença pelo coronavírus 2019 (COVID-19) no Brasil pelo Ministério da Saúde. 2021.
Brasil. Observatório Obstétrico Brasileiro. OOBr SRAG: Síndrome respiratória aguda grave em gestantes e puérperas. 2023. Disponível em: https://observatorioobstetrico.shinyapps.io/covid_gesta_puerp_br.
Pacheco ES, da Silva VR, Soares LS. A brief epidemiological analysis of COVID-19 in Piauí, Brazil. Rev Prev Infec Saude. 2020;6.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020 May;222(5):415-426. doi: 10.1016/j.ajog.2020.02.017.
Rozycki HJ, Kotecha S. Covid-19 in pregnant women and babies: What pediatricians need to know. Paediatr Respir Rev. 2020 Sep;35:31-37. doi: 10.1016/j.prrv.2020.06.006.
Shah PS, Diambomba Y, Acharya G, Morris SK, Bitnun A. Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates. Acta Obstet Gynecol Scand. 2020 May;99(5):565-568. doi: 10.1111/aogs.13870.
Almeida VRS, Farias RV, Morais AC, Estrela FM, Soares CFS, Araújo RS, Nascimento DC, Leitão DS, Moura JCV, Silva JMS. Características clínicas, laboratoriais e radiológicas da COVID-19 em crianças. Braz. J. Develop. 2021 Jan. 25;7(1):9601-15. doi: 10.34117/bjdv7n1-650.
Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020 Jun;109(6):1088-1095. doi: 10.1111/apa.15270.
Brasil. Nota técnica nº 14/2020-COCAM/CGCIVI/DAPES/SAPS/MS- Atenção à saúde do recém-nascido no contexto da infecção pelo novo Coronavírus (SARS-CoV-2). 2020.
Neto JC, Feitosa EMS, Silva KVLG, Oliveira CJ. Análise de indicadores epidemiológicos de crianças e adolescentes acometidos pela Covid-19 no Nordeste do Brasil. Rev Enferm UFSM [Internet]. 2021;11:e19. doi: 10.5902/2179769263043.
Kimberlin DW, Stagno S. Can SARS-CoV-2 Infection Be Acquired In Utero?: More Definitive Evidence Is Needed. JAMA. 2020;323(18):1788-1789. doi: 10.1001/jama.2020.4868.
SPSP (São Paulo). Departamento Científico de Neonatologia da SPSP. Coronavírus e recém-nascido: O que se sabe até o momento? São Paulo. 2020;3.
Yang Z, Liu Y. Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review. Am J Perinatol. 2020 Aug;37(10):1055-1060. doi: 10.1055/s- 0040-1712161.
Gil AC. Como elaborar projetos de pesquisa. 6ª ed. São Paulo: Atlas; 2017.
Hulley SB, et al. Delineando a pesquisa clínica. 4ª ed. Porto Alegre: Artmed; 2015.
SESAPI (Piauí). Maternidade Evangelina Rosa. Portal do Governo do Estado do Piauí. 2021. Disponível em: http://www.saude.pi.gov.br/paginas/maternidade-evangelina-rosa.
Conselho Nacional de Saúde. Resolução nº 466, de 12 de dezembro de 2012. Aprovar diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Diário Oficial da União. 13 jun. 2013.
Brito JGE, et al. Características clínicas, sociodemográficas e desfechos de gestantes hospitalizadas com COVID-19. Res Soc Dev. 2021;10(17):e33101723049. doi: 10.33448/rsd-v10i17.23049
Pitilin EB, Lentsck MH, Gasparin VA, Falavina LP, Conceição VM, Oliveira PP, Baratieri T. COVID em mulheres no Brasil: tempo de permanência e status das primeiras internações. Rev. Rene. 2021; 22: e61049.
Costa LD, Ruaro FC, Popp AN, Roll JS, Bruxel ECD, Fachinello G, Girardi E, Perondi AR. Desfechos de partos em gestantes que positivaram COVID-19 em município paranaense. Revista de Saúde Pública do Paraná [Internet]. 2022;5(2). doi: 10.32811/25954482-2022v5n2.615.
Gonçalves ZR, Monteiro DLM. Complicações maternas em gestantes com idade avançada. Femina. 2012;40(5):275-9.
Souza ASR, Amorim MMR. Mortalidade materna pela COVID-19 no Brasil. Rev Bras Saúde Saúde Mater Infant. 2021;21(Suppl.1):253-6. doi: 10.1590/1806- 9304202100S100014.
Albuquerque LP, Monte AVL, Araújo RMS. Implicações da COVID-19 para pacientes gestantes. Rev Eletrônica Acervo Saúde. 2020;12(10):e4632. doi: 10.25248/reas.e4632.2020
Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020 Mar 7;395(10226):809-815. doi: 10.1016/S0140- 6736(20)30360-3.
Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z. Clinical characteristics of 19 neonates born to mothers with COVID-19. FM. 2020;14(2):193-198. doi: 10.1007/s11684-020-0772-y.
Lyra J, Valente R, Rosário M, Guimarães M. Cesarean Section in a Pregnant Woman with COVID-19: First Case in Portugal. Acta Med Port. 2020 Jun 1;33(6):429-431. doi: 10.20344/amp.13883.
Ozsurmeli M, Terzi H, Hocaoglu M, Bilir RA, Gunay T, Unsal D, Turgut A, Karateke A. Clinical characteristics, maternal and neonatal outcomes of pregnant women with SARS- CoV-2 infection in Turkey. Bratisl Lek Listy. 2021;122(2):152-157. doi: 10.4149/BLL_2021_023.
Brasil. Ministério da Saúde. Manual de gestação de alto risco [recurso eletrônico]. Brasília: Ministério da Saúde; 2022.
Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, Ji R, Wang H, Wang Y, Zhou Y. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020 May;94:91-95. doi: 10.1016/j.ijid.2020.03.017.
Hazari K, Abdeldayem R,Paulose L,Kurien N,Almahloul Z, Mohammad H, et al. Covid-19 infection inpreg-nant women inDubai: acase-control study. BMC Pregnancy Childbirth. 2021;21(1):658-92. doi: 10.1186/s12884-021-04130-8.
Queiroz VAM, et al. Principais complicações obstétricas causadas pelo COVID-19. Res Soc Dev. 2023;12(1):e27412139823. doi: 10.33448/rsd-v12i1.39823
Litman EA, Yin Y, Nelson SJ, Capbarat E, Kerchner D, Ahmadzia HK. Adverse perinatal outcomes in a large United States birth cohort during the COVID-19 pandemic. Am J Obstet Gynecol MFM. 2022 May;4(3):100577. doi: 10.1016/j.ajogmf.2022.100577.
Almeida CPF, Silva JA, Araújo JIF, Azevedo ÁCB. Assistência ao pré-natal no Rio Grande do Norte: acesso e qualidade do cuidado na atenção básica. Rev Cien Plural [Internet]. 2021;7(3):61–80. doi: 10.21680/2446-7286.2021v7n3ID22151
Thomé MT, Amaral GR, Miranda CC, Amaral LM, Miranda SS, Ramos RS, Rezende BCE, Campelo GQ. Análise do pré-natal e do apgar no 1 minuto de nascidos vivos em 2018. Braz. J. Develop. 2020;6(8):54384–92. doi: 10.34117/bjdv6n8-015
Boushra MN, Koyfman A, Long B. COVID-19 in pregnancy and the puerperium: A review for emergency physicians. Am J Emerg Med. 2021 Feb;40:193-198. doi: 10.1016/j.ajem.2020.10.055.
Papapanou M, Papaioannou M, Petta A, Routsi E, Farmaki M, Vlahos N, Siristatidis C. Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews. Int J Environ Res Public Health. 2021 Jan 12;18(2):596. doi: 10.3390/ijerph18020596.
Dhir SK, Kumar J, Meena J, Kumar P. Clinical Features and Outcome of SARS-CoV-2 Infection in Neonates: A Systematic Review. J Trop Pediatr. 2021 Jul 2;67(3):fmaa059. doi: 10.1093/tropej/fmaa059.
Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, Liu Y, Xiao J, Liu H, Deng D, Chen S, Zeng W, Feng L, Wu J. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020 May;20(5):559-564. doi: 10.1016/S1473-3099(20)30176-6.
Brasil. Nota Informativa nº 13/2020 – SE/GAB/SE/MS – Manual de Recomendações para a Assistência à Gestante e Puérpera frente à Pandemia de Covid-19 [recurso eletrônico]. Brasília: Ministério da Saúde; 2020.
Hassoun A, Dahan N, Kelly C. A Case Series of SARS-CoV-2 RT-PCR-Positive Hospitalized Infants 60 Days of Age or Younger From 2 New York City Pediatric Emergency Departments. Clinical Pediatrics. 2021;60(4-5):247-251. doi: 10.1177/00099228211006688.
Sociedade de Pediatria de São Paulo. Coronavírus e recém-nascido: o que se sabe até o momento? São Paulo: Sociedade de Pediatria de São Paulo; 2020.
Carvalho AS, Franco JM, Maciel MCB, Alves SFL, Stermer PRR, Filho LECS, Chermont AG, Chermont AG, Cunha KC. Mortalidade por síndrome de aspiração meconial em recém-nascidos no estado do Pará, Região Norte do Brasil. REAS [Internet]. 2020;12(5):e2743. doi: 10.25248/reas.e2743.2020.
Domingues CSB, Duarte G, Passos MRL, Sztajnbok DCN, Menezes MLB. Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: sífilis congênita e criança exposta à sífilis. Epidemiol. Serv. Saúde [Internet]. 2021;30(esp): e2020597. doi: 10.1590/s1679-4974202100005.esp1.
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Copyright (c) 2025 Ana Carolina de Macêdo Lima, Mayara Callado Silva Moura, Álvaro Sepúlveda Carvalho Rocha, Brenda Maria dos Santos de Melo, Girzia Sammya Tarja Rocha, Maria Zélia Araújo Madeira, Odinéa Maria Amorim Batista
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