Cost of antimicrobial therapy in hospitalized adult patients with multidrug-resistant microorganism infections
DOI:
https://doi.org/10.26694/repis.v11i1.6107Keywords:
Multiple bacterial drug resistance, Hospital infection, Health care costs, Drug costs, Nursing.Abstract
Introduction: Antimicrobial resistance has increased alarmingly in recent decades and makes a challenge to health systems; it increases hospital stays, expenses, and the risk of disability and death. Objective: To rate the costs of antimicrobial treatment in adults infected with multidrug-resistant microorganisms in a tertiary hospital. Method: A retrospective, cross-sectional study with a quantitative approach was carried out in a tertiary hospital in southern Brazil, from January 2018 to December 2023. Clinical, demographic, and cost variables were accessed from the electronic medical records of patients >18 years old with positive microbiological cultures. The data were subjected to descriptive statistical analysis and multiple linear regression using the "enter" method. Results: Among 3,452 hospitalizations, 781 patients had positive cultures, 73.1% for multidrug-resistant microorganisms. The median age was 65 years, with a predominance of males (60.7%). 57.2% died; 73.6% had cultures for multidrug-resistant microorganisms. The average cost of antimicrobials for patients with infections caused by multidrug-resistant microorganisms was US$684.77; and for patients with infections caused by sensitive microorganisms, it was US$333.10. Conclusion: The expense of antimicrobial treatment in adult patients infected with multidrug-resistant microorganisms was twice as high as in infections caused by antimicrobial-sensitive microorganisms.
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Copyright (c) 2025 Susany Franciely Pimenta, Larissa Ribeiro de Andrade, Rosângela Aparecida Pimenta, Nayane Laine Paglione Dias
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